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Juvenile hormone shortens silkworm lifespan
The study showed that juvenile hormone (JH) and its analog can shorten the survival of male silkworm, while allatostatin, which inhibits JH secretion, extends survival. JH reduces a pro-longevity transcription factor, FoxO, and regulates it through a JH response element. A JH-binding protein, BmTO, functions as a target of FoxO,…
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Frontal lobe transcriptomics identifies key mitophagy gene changes in AD patients
This study analyzed frontal lobe transcriptomic data to identify mitophagy gene changes in Alzheimer’s disease (AD) brain. They found 299 candidate mitophagy-related differentially expressed genes in AD patients, with four key genes showing down-regulation. Validation in human in vitro models suggested their relevance as potential AD biomarkers or pharmacological targets.
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Astragalus polysaccharide extends lifespan in silkworm
A study in Aging and Disease 2019 reveals that Astragalus polysaccharide (APS) extends the silkworm’s lifespan by mitigating endoplasmic reticulum stress. APS increases lifespan and body weight, enhances antioxidant enzyme activities, and rescues lifespan from infection. It also ameliorates endoplasmic reticulum stress. The findings shed light on APS-induced lifespan extension…