Category: DNA repair
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TIP60 in aging and neurodegeneration
TIP60, a histone acetyltransferase, regulates diverse pathways like autophagy, DNA repair, and neuronal functions, impacting aging and neurodegeneration. It holds promise as a therapeutic target for Alzheimer’s disease. Drosophila models provide insight into its neurobiological roles. Understanding TIP60’s functions may contribute to maintaining cellular homeostasis and counteracting aging and neurodegeneration.
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New hallmarks of ageing
The new hallmarks of ageing, discussed in a 2022 Copenhagen meeting, expand on the original nine proposed in 2013. These new hallmarks include compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation. Understanding these hallmarks may lead to interventions for healthy aging and age-related diseases.
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Genomic instability and aging
The mammalian DNA damage response involves various repair pathways to address diverse DNA lesions caused by damaging agents like UV and chemicals. Genomic instability plays a critical role in aging, contributing to age-related diseases. To combat this, interventions like physical exercise, dietary restriction, supplementation, and DNA repair stimulation can attenuate…
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Nicotinamide riboside rescues Rev1 deficiency
Rev1 deficiency causes metabolic shift and mitochondrial dysfunction in MEFs. NAD+ precursor nicotinamide riboside can manipulate these effects. Autophagy decreases in Rev1-/- MEFs but can be restored with NR supplementation. Abnormal mitochondrial morphology can be partially reversed with NR, which also protects mitochondrial cristae. Rev1 deficiency leads to metabolic dysregulation,…