Category: Natural Compounds
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Urolithin A improves Alzheimer’s disease
Urolithin A (UA) enhances cGAS-STING activation, promoting cytosolic DNA clearance and modulating innate immune responses. This makes UA a potential therapeutic option for diseases involving cGAS-STING pathway activation or cytosolic DNA accumulation, with no reported adverse effects in animal models and limited human trials. Further research in relevant animal models…
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Salidroside promotes healthy longevity
The study investigates the impact of salidroside (SA) from Rhodiola rosea on lifespan and healthspan. SA binds to HSP90, reducing oxidation and extending lifespan. It inhibits HSP90’s ATPase activity, affecting protein interaction and gene expression. This reveals SA’s potential as an anti-aging drug and antioxidative agent, crucial for human health.
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Urolithin A modulates the cGAS-STING signaling pathway
Urolithin A (UA) enhances cGAS-STING activation, promoting cytosolic DNA clearance and modulating innate immune responses. This makes UA a potential therapeutic option for diseases involving cGAS-STING pathway activation or cytosolic DNA accumulation, with no reported adverse effects in animal models and limited human trials. Further research in relevant animal models…
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Genomic instability and aging
The mammalian DNA damage response involves various repair pathways to address diverse DNA lesions caused by damaging agents like UV and chemicals. Genomic instability plays a critical role in aging, contributing to age-related diseases. To combat this, interventions like physical exercise, dietary restriction, supplementation, and DNA repair stimulation can attenuate…
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Nicotinamide riboside rescues Rev1 deficiency
Rev1 deficiency causes metabolic shift and mitochondrial dysfunction in MEFs. NAD+ precursor nicotinamide riboside can manipulate these effects. Autophagy decreases in Rev1-/- MEFs but can be restored with NR supplementation. Abnormal mitochondrial morphology can be partially reversed with NR, which also protects mitochondrial cristae. Rev1 deficiency leads to metabolic dysregulation,…
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Polyphenols in oral health
Polyphenols, bioactive compounds found in human diets, offer antioxidant, antibacterial, and anti-inflammatory properties with potential to prevent oral and systemic diseases. While their specific effects on oral microbiota and health are not fully understood, research highlights their impact on dental caries, periodontal diseases, halitosis, and oral cancer. Promising applications in…
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Lycium barbarum polysaccharide improves Parkinson’s in silkworm
The study identified 17 Fox genes in the silkworm, classified into 13 subfamilies. The genes have varied expression patterns in larval tissues and play roles in cellular components and biological processes. Purifying selection acts on most amino acid sites.