Category: Inflammation
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Urolithin A modulates the cGAS-STING signaling pathway
Urolithin A (UA) enhances cGAS-STING activation, promoting cytosolic DNA clearance and modulating innate immune responses. This makes UA a potential therapeutic option for diseases involving cGAS-STING pathway activation or cytosolic DNA accumulation, with no reported adverse effects in animal models and limited human trials. Further research in relevant animal models…
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New hallmarks of ageing
The new hallmarks of ageing, discussed in a 2022 Copenhagen meeting, expand on the original nine proposed in 2013. These new hallmarks include compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation. Understanding these hallmarks may lead to interventions for healthy aging and age-related diseases.
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Genomic instability and aging
The mammalian DNA damage response involves various repair pathways to address diverse DNA lesions caused by damaging agents like UV and chemicals. Genomic instability plays a critical role in aging, contributing to age-related diseases. To combat this, interventions like physical exercise, dietary restriction, supplementation, and DNA repair stimulation can attenuate…
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Polyphenols in oral health
Polyphenols, bioactive compounds found in human diets, offer antioxidant, antibacterial, and anti-inflammatory properties with potential to prevent oral and systemic diseases. While their specific effects on oral microbiota and health are not fully understood, research highlights their impact on dental caries, periodontal diseases, halitosis, and oral cancer. Promising applications in…